High Acceptability of an Orally Dispersible Tablet Formulation by Children

There is a high unmet medical need for child-appropriate oral dosage forms. The acceptability of novel placebo orally dispersible tablet formulation (pODT) was therefore evaluated. Monolithic tablets contain an inorganic calcium carbonate/calcium phosphate carrier material as the main excipient. They were assessed in cross-sectional study. 40 child participants between 2 to 5 years and 6 10 old. One pODT with mm diameter administered each participating by placement on tongue or into buccal cavity. Parents asked complete questionnaire together study personnel. spontaneous reactions children recorded. ease administration children’s acceptance rated research staff 4-point scale parents 5-point Likert scale. older subjects answered how they had liked pointing appropriate face Facial Hedonic Scale. very 93% parents, all questioned reported be acceptable acceptable. Staff administering these without problems. None showed distress receipt pODT. We conclude that proposed child-friendly form provides convenient option drug expected enhance drug-adherence pediatric patients.